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Parkinson's disease PD is a progressive neuronal degenerative brain disease of the elderly, and is caused by the selective degeneration of neurons in the substantia nigra SN region of the brain, resulting in a reduced production of the neurotransmitter dopamine. The purpose of this study was to test the hypothesis that oxidative phosphorylation uncoupling agents would antagonize the effect of rotenone on NMDA current.
This study assesses whether abnormal echogenicity of the substantia nigra SN and raphe nuclei RN and the diameter of third ventricle are markers of cognitive impairment in patients with Asian sex Kongens Lyngby and other forms of parkinsonism.
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Post-mortem analysis of p62 is a defining diagnostic marker in several neurodegenerative diseases including amyotrophic lateral sclerosis and inclusion body webstr. In our previous study on rat brains, we observed that a two-generation EFA dietary restriction reduced the number and size of dopaminergic neurons in the substantia nigra SN rostro-dorso-medial.
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